Relay Platform
Unlocking protein motion to transform drug discovery for previously intractable targets.
Executive Summary
The Relay Dynamo™ Platform is a proprietary, integrated R&D engine used by Relay Therapeutics to accelerate small molecule drug discovery. It leverages advanced machine learning, molecular dynamics simulations, and experimental techniques to understand protein motion, enabling the design of precision medicines for oncology and genetic diseases. The platform's differentiation lies in its ability to identify and drug previously intractable protein targets by focusing on their dynamic behavior rather than static structures, providing a significant advantage in developing novel therapeutics.
Use Cases
- Identifying novel drug targets by understanding protein dynamics.
- Designing small molecule drugs with improved specificity and potency.
- Optimizing lead compounds for desired therapeutic characteristics.
- Accelerating the drug discovery process from hit identification to lead optimization.
- Addressing previously intractable disease pathways in oncology and genetic diseases.
Features
Visibility
- Protein Dynamics Visualization: Visualizes the three-dimensional motion of proteins over biologically relevant timescales to reveal dynamic conformations and binding sites.
- Experimental Data Integration: Integrates data from Cryo-EM, X-ray crystallography, and other biophysical experiments for a comprehensive understanding of protein structure and function.
- Computational Screening Results: Displays results from virtual screens of billions of molecules, highlighting potential chemical starting points and their predicted interactions.
Intelligence
- AI-Powered Target Identification: Utilizes machine learning to identify novel binding sites and previously 'undruggable' protein targets by analyzing protein motion.
- Molecular Dynamics Simulations: Performs long-timescale molecular dynamics simulations to generate virtual simulations of full-length protein movement.
- Predictive Drug Property Modeling: Predicts and designs compounds with desired characteristics such as potency, selectivity, and bioavailability, accelerating lead optimization.
- DNA-Encoded Library (DEL) ML: Incorporates machine learning powered DNA-encoded library (REL-DEL) data to rapidly identify and prioritize chemical starting points.
Support
- Internal Scientific Support: Dedicated internal teams provide scientific and technical support to researchers utilizing the Dynamo™ platform.
- Platform Development & Maintenance: Continuous internal development, updates, and maintenance ensure the platform remains at the cutting edge of computational and experimental capabilities.
Technical Specifications
- Architecture
- Cloud-native, high-performance computing (HPC) environment leveraging specialized supercomputers and cloud services.
- Deployment
- Internal/Proprietary Cloud/SaaS
- Authentication
- Internal corporate authentication mechanisms
- API Available
- No
- MCP Server
- No
Infrastructure
- AWS
- GCP
- D.E. Shaw Research Anton 2 supercomputer
AI/ML Stack
- Machine Learning
- Molecular Dynamics Simulations
- Physics-based Simulations
- Computational Biology
- Deep Learning
Integrations
- Cryo-EM
- Molecular Dynamics
Security & Compliance
Certifications: Internal compliance with pharmaceutical R&D data security standards
Encryption: Standard enterprise-grade encryption for data at rest and in transit.
Pricing
- Model
- Not applicable (internal proprietary platform)
- Starting Price
- Not applicable (internal proprietary platform)
- Target Customer
- Relay Therapeutics (internal use)
- Contract Type
- Not applicable (internal proprietary platform)
- Free Trial
- No (credit card required)
About Relay Therapeutics
Relay Therapeutics is a clinical-stage precision medicine company transforming the drug discovery process by combining leading-edge computational and experimental technologies. They focus on making small molecule medicines against precision medicine targets, with an initial focus on oncology and genetic disease.